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Endophenotype Group

Endophenotypes are measurable and heritable traits or behaviors linked to a disorder, that sit between the genetic factors and the observable symptoms of the condition. Psychiatric disorders are increasingly viewed as neurodevelopmental disorders, which are influenced by genetic, epigenetic & environmental factors. These clues offer insights into genetic underpinnings of these disorders. Utilising endophenotypes derived from various assessments like neuroimaging can enhance the reliability of research on brain function.

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Featured Publications​

Parekh P, Vivek Bhalerao G; ADBS consortium, John JP, Venkatasubramanian G. Sample size requirement for achieving multisite harmonization using structural brain MRI features. Neuroimage. 2022;264:119768. doi:10.1016/j.neuroimage.2022.119768

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Lakkireddy SP, Balachander S, Dayalamurthy P, et al. Neurocognition and its association with adverse childhood experiences and familial risk of mental illness. Prog Neuropsychopharmacol Biol Psychiatry. 2022;119:110620. doi:10.1016/j.pnpbp.2022.110620

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Bhalerao GV, Parekh P, Saini J, Venkatasubramanian G, John JP; ADBS consortium. Systematic evaluation of the impact of defacing on quality and volumetric assessments on T1-weighted MR-images. J Neuroradiol. 2022;49(3):250-257. doi:10.1016/j.neurad.2021.03.001

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Parekh P, Bhalerao GV, Rao R, et al. Protocol for magnetic resonance imaging acquisition, quality assurance, and quality check for the Accelerator program for Discovery in Brain disorders using Stem cells. Int J Methods Psychiatr Res. 2021;30(3):e1871. doi:10.1002/mpr.1871

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Holla B, Dayal P, Das A, et al. Transdiagnostic neurocognitive endophenotypes in major psychiatric illness. medRxiv (Cold Spring Harbor Laboratory). February 2020. doi:10.1101/2020.02.14.20022863

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